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KMID : 0378119860130020354
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Chungnam Medical Journal
1986 Volume.13 No. 2 p.354 ~ p.359
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A Study for the Antagonistic Effects of Pyridostigmine and Neostigmine for Neuromuscular Blocking Agent
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Abstract
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This present study was undertaken to observe the effects of pyridostigmine and neostigmine on heart rate and it´s antagonistic effect on pancuronium in 62 patients during general anesthesia.
We observed the effect of pyridostigmine and neostigmine with atropine and glycopyrrolate on heart rate, appearance of arrhythmia, time required for returning of spontaneous breath and sustained tetanic response and effect on the amount o: secretion in oral cavity and trachea.
The result are as follows:
1. The incidence of bradycardia was the highest in the group of atropine and neostigmine i.v. administration together, and the lowest in the group of glycopyrrolate and pyridostigmine i.v. administration together.
2. The incidence of tachycardia was the highest in the group of atropine and pyridostigmine i.v. administration together, and the least in the group of glycoplrrrolate and pyridostigmine i.v. administration together.
3. Among the experimental cases, only one showed arrhythmia which is PVC.
4. The time required for returning of spontaneous respiration was 4.6-6.1 minutes range in all groups.
5. The group of glycopyrrolate administrated showed the greatest antisialogue effect.
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